Revascularization after angiogenesis inhibition favors new sprouting over abandoned vessel reuse.

ABSTRACT: Inhibiting pathologic angiogenesis can halt disease progression, but such inhibition may offer only a temporary benefit, followed by tissue revascularization after treatment stoppage. This revascularization, however, occurs by largely unknown phenotypic changes in pathologic vessels. To investigate the dynamics of vessel reconfiguration during revascularization, we developed a model of reversible murine corneal angiogenesis permitting longitudinal examination of the same vasculature. Following 30 days of angiogenesis inhibition, two types of vascular structure were evident: partially regressed persistent vessels that were degenerate and barely functional, and fully regressed, non-functional empty basement membrane sleeves (ebms). While persistent vessels maintained a limited flow and retai

SUBMITTER: Mukwaya A 

PROVIDER: S-EPMC6863948 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature