Modeling the role of endoplasmic reticulum-mitochondria microdomains in calcium dynamics.

ABSTRACT: Upon inositol trisphosphate (IP₃) stimulation of non-excitable cells, including vascular endothelial cells, calcium (Ca²⁺) shuttling between the endoplasmic reticulum (ER) and mitochondria, facilitated by complexes called Mitochondria-Associated ER Membranes (MAMs), is known to play an important role in the occurrence of cytosolic Ca²⁺ concentration ([Ca²⁺]_Cyt) oscillations. A mathematical compartmental closed-cell model of Ca²⁺ dynamics was developed that accounts for ER-mitochondria Ca²⁺ microdomains as the µd compartment (besides the cytosol, ER and mitochondria), Ca²⁺ influx to/efflux from each compartment and Ca²⁺ buffering. Varying the distribution of functional receptors in MAMs vs. th

SUBMITTER: Moshkforoush A 

PROVIDER: S-EPMC6864103 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature