The genetic association study of TP53 polymorphisms in Saudi obese patients.

ABSTRACT: Obesity is a multifactorial metabolic disorder characterized by low grade chronic inflammation. Rare and novel mutations in genes which are vital in several key pathways have been reported to alter the energy expenditure which regulates body weight. The TP53 or p53 gene plays a prominent role in regulating various metabolic activities such as glycolysis, lipolysis, and glycogen synthesis. Recent genome-wide association studies reported that tumor suppressor gene p53 variants play a critical role in the predisposition of type 2 diabetes and obesity. Till date, no reports are available from the Arabian population; hence the present study was intended to assess the association between p53 variants with risk of obesity development in the Saudi population. We have selected three p53 polymorphis

SUBMITTER: Sabir JSM 

PROVIDER: S-EPMC6864141 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature