The IL-12- and IL-23-Dependent NK Cell Response Is Essential for Protective Immunity against Secondary Toxoplasma gondii Infection.

ABSTRACT: NK cells can develop cell-intrinsic memory-like characteristics. Whether they develop these characteristics during Toxoplasma gondii infection is unknown. We addressed this question and dissected the mechanisms involved in secondary NK cell responses using a vaccine-challenge mouse model of T. gondii infection. NK cells were required for control of and survival after secondary T. gondii infection. NK cells increased in number at the reinfection site and produced IFN-γ. To test if these T. gondii experienced NK cells were intrinsically different from naive NK cells, we performed NK cell adoptive transfer into RAG2/cγ-chain^-/- mice, NK cell fate mapping, and RAG1^-/- mice vaccine-challenge experiments. Although NK cells contributed to immunity

SUBMITTER: Ivanova DL 

PROVIDER: S-EPMC6864276 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature