Protective responses of an engineered PspA recombinant antigen against Streptococcus pneumoniae.

ABSTRACT: Streptococcus pneumoniae is a major pathogen in human respiratory tract which causes significant morbidity and mortality across from the world. Currently available vaccines are not completely effective and cannot cover all pathogenic strains so there is an important need to develop an alternative cost-effective vaccine, based on conserved protein antigens. Pneumococcal surface protein A (PspA) is one of interesting candidates for development of a serotype-independent vaccine against pneumococcal infections. PspA is grouped into two major families with five clades, and broad-reacting PspA-based vaccines should contain at least one functional fragment from each of the two families. In this study, we developed two immunogenic antigens based on recombinant PspA proteins that including t

SUBMITTER: Akbari E 

PROVIDER: S-EPMC6864353 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature