Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates.

ABSTRACT: A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

SUBMITTER: Tomassetti M 

PROVIDER: S-EPMC6864457 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature