A LAPS-Based Differential Sensor for Parallelized Metabolism Monitoring of Various Bacteria.

ABSTRACT: Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH va

SUBMITTER: Dantism S 

PROVIDER: S-EPMC6864667 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature