Molecular Variants and Their Risks for Malignancy in Cytologically Indeterminate Thyroid Nodules.

ABSTRACT: Background: Gene panels are routinely used to assess predisposition to hereditary cancers by simultaneously testing multiple susceptibility genes and/or variants. More recently, genetic panels have been implemented as part of solid tumor malignancy testing assessing somatic alterations. One example is targeted variant panels for thyroid nodules that are not conclusively malignant or benign upon fine-needle aspiration (FNA). We systematically reviewed published studies from 2009 to 2018 that contained genetic data from preoperative FNA specimens on cytologically indeterminate thyroid nodules (ITNs) that subsequently underwent surgical resection. Pooled prevalence estimates per gene and variant, along with their respective positive predictive values (PPVs) for malignancy, were

SUBMITTER: Goldner WS 

PROVIDER: S-EPMC6864764 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature