Novel Hit Compounds as Putative Antifungals: The Case of Aspergillus fumigatus.

ABSTRACT: The prevalence of invasive fungal infections has been dramatically increased as the size of the immunocompromised population worldwide has grown. Aspergillus fumigatus is characterized as one of the most widespread and ubiquitous fungal pathogens. Among antifungal drugs, azoles have been the most widely used category for the treatment of fungal infections. However, increasingly, azole-resistant strains constitute a major problem to be faced. Towards this direction, our study focused on the identification of compounds bearing novel structural motifs which may evolve as a new class of antifungals. To fulfil this scope, a combination of in silico techniques and in vitro assays were implemented. Specifically, a ligand-based pharmacophore model was created and served as a 3D search query

SUBMITTER: Kritsi E 

PROVIDER: S-EPMC6864791 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature