MR-based age-related effects on the striatum, globus pallidus, and thalamus in healthy individuals across the adult lifespan.

ABSTRACT: While numerous studies have used magnetic resonance imaging (MRI) to elucidate normative age-related trajectories in subcortical structures across the human lifespan, there exists substantial heterogeneity among different studies. Here, we investigated the normative relationships between age and morphology (i.e., volume and shape), and microstructure (using the T1-weighted/T2-weighted [T1w/T2w] signal ratio as a putative index of myelin and microstructure) of the striatum, globus pallidus, and thalamus across the adult lifespan using a dataset carefully quality controlled, yielding a final sample of 178 for the morphological analyses, and 162 for the T1w/T2w analyses from an initial dataset of 253 healthy subjects, aged 18-83. In accordance with previous cross-sectional studies of adults,

SUBMITTER: Tullo S 

PROVIDER: S-EPMC6864890 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature