Abnormal neural functions associated with motor inhibition deficits in schizophrenia and bipolar disorder.

ABSTRACT: Deficits in response inhibition have been observed in schizophrenia and bipolar disorder; however, the neural origins of the abnormalities and their relevance to genetic liability for psychosis are unknown. We used a stop-signal task to examine motor inhibition and associated neural processes in schizophrenia patients (n = 57), bipolar disorder patients (n = 21), first-degree biological relatives of patients with schizophrenia (n = 34), and healthy controls (n = 56). Schizophrenia patients demonstrated motor control deficits reflected in longer stop-signal reaction times and elongated reaction times. With the possibility of needing to inhibit a button press, both schizophrenia and bipolar disorder patients showed diminished reductions of the P300 brain response and only the healthy control

SUBMITTER: Van Voorhis AC 

PROVIDER: S-EPMC6864893 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature