Joint contributions of cortical morphometry and white matter microstructure in healthy brain aging: A partial least squares correlation analysis.

ABSTRACT: Cortical atrophy and degraded axonal health have been shown to coincide during normal aging; however, few studies have examined these measures together. To lend insight into both the regional specificity and the relative timecourse of structural degradation of these tissue compartments across the adult lifespan, we analyzed gray matter (GM) morphometry (cortical thickness, surface area, volume) and estimates of white matter (WM) microstructure (fractional anisotropy, mean diffusivity) using traditional univariate and more robust multivariate techniques to examine age associations in 186 healthy adults aged 20-94 years old. Univariate analysis of each tissue type revealed that negative age associations were largest in frontal GM and WM tissue and weaker in temporal, cingulate, and occipital

SUBMITTER: Hoagey DA 

PROVIDER: S-EPMC6864896 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature