Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis.

ABSTRACT: In schizophrenia patients, cognitive functions appear linked to widespread alterations in cerebral white matter microstructure. Here we examine patterns of associations between regional white matter and cognitive functions in individuals at ultra-high risk for psychosis. One hundred and sixteen individuals at ultra-high risk for psychosis and 49 matched healthy controls underwent 3 T magnetic resonance diffusion-weighted imaging and cognitive assessments. Group differences on fractional anisotropy were tested using tract-based spatial statistics. Group differences in cognitive functions, voxel-wise as well as regional fractional anisotropy were tested using univariate general linear modeling. Multivariate partial least squares correlation analyses tested for associations between patterns o

SUBMITTER: Kristensen TD 

PROVIDER: S-EPMC6864899 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature