Ontology highlight
ABSTRACT:
SUBMITTER: Fuchs TA
PROVIDER: S-EPMC6864900 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Human brain mapping 20190824 18
Cognitive reserve is one's mental resilience or resistance to the effects of structural brain damage. Reserve effects are well established in people with multiple sclerosis (PwMS) and Alzheimer's disease, but the neural basis of this phenomenon is unclear. We aimed to investigate whether preservation of functional connectivity explains cognitive reserve. Seventy-four PwMS and 29 HCs underwent neuropsychological assessment and 3 T MRI. Structural damage measures included gray matter (GM) atrophy ...[more]