Proactive inhibition deficits with normal perfusion after pediatric mild traumatic brain injury.

ABSTRACT: Although much attention has been generated in popular media regarding the deleterious effects of pediatric mild traumatic brain injury (pmTBI), a paucity of empirical evidence exists regarding the natural course of biological recovery. Fifty pmTBI patients (12-18 years old) were consecutively recruited from Emergency Departments and seen approximately 1 week and 4 months post-injury in this prospective cohort study. Data from 53 sex- and age-matched healthy controls (HC) were also collected. Functional magnetic resonance imaging was obtained during proactive response inhibition and at rest, in conjunction with independent measures of resting cerebral blood flow. High temporal resolution imaging enabled separate modeling of neural responses for preparation and execution of proactive respons

SUBMITTER: Mayer AR 

PROVIDER: S-EPMC6864901 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature