The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.

ABSTRACT:

Background

The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.

Results

Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for gen

SUBMITTER: Zhou N 

PROVIDER: S-EPMC6864930 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature