Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer.

ABSTRACT:

Aim

Cervical cancer is a common malignant carcinoma of the gynecological tract with high morbidity and mortality. Therefore, it is crucial to elucidate the pathogenesis, prevention, diagnosis and prognosis of cervical cancer by searching for the involved key genes.

Method

In this study, the alternative splicing (AS) events of 253 patients with cervical cancer were analyzed, and 41,766 AS events were detected in 9961 genes. Univariate analysis was performed to screen prognostic AS events. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was used to identify the pathways in which these AS events were involved.

Results

We found that exon skip (ES) is the main AS event in patients with cervical cancer. There was pronounced consistency between the genes i

SUBMITTER: Hu YX 

PROVIDER: S-EPMC6865056 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature