The Association of UNC13B Gene Polymorphisms and Diabetic Kidney Disease in a Chinese Han Population.

ABSTRACT: BACKGROUND Polymorphisms in the UNC13B gene are associated with diabetic kidney disease (DKD) in the European population. Asian populations are more likely to suffer from complications of type 2 diabetes mellitus (T2DM), including diabetic kidney disease (DKD). This case-control study aimed to investigate the association between UNC13B gene polymorphisms and DKD in a Chinese Han population. MATERIAL AND METHODS Five single nucleotide polymorphism (SNP) loci (rs13293564, rs17360668, rs10114937, rs661712, and rs2281999) were genotyped in the UNC13B gene in 600 Chinese Han subjects. The study population included patients with T2DM with DKD (N=292) and control patients with T2DM without DKD (N=308). SNP genotyping was performed using a Sequenom MassARRAY system using chip-based matrix-assisted

SUBMITTER: Wang Y 

PROVIDER: S-EPMC6865244 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature