Association of Cardiac Resynchronization Therapy With Change in Left Ventricular Ejection Fraction in Patients With Chemotherapy-Induced Cardiomyopathy.

ABSTRACT:

Importance

The incidence of chemotherapy-induced cardiomyopathy is increasing and is associated with poor clinical outcomes.

Objective

To assess the association of cardiac resynchronization therapy (CRT) with improvement in cardiac function, as well as clinical improvement in patients with chemotherapy-induced cardiomyopathy.

Design, setting, and participants

The Multicenter Automatic Defibrillator Implantation Trial-Chemotherapy-Induced Cardiomyopathy was an uncontrolled, prospective, cohort study conducted between November 21, 2014, and June 21, 2018, at 12 tertiary centers with cardio-oncology programs in the United States. Thirty patients were implanted with CRT owing to reduced left ventricular ejection fraction (LVEF≤35%), New York Heart Association class II-IV

SUBMITTER: Singh JP 

PROVIDER: S-EPMC6865289 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature