Two-Year Neurodevelopmental Outcomes After Mild Hypoxic Ischemic Encephalopathy in the Era of Therapeutic Hypothermia.

ABSTRACT:

Importance

Therapeutic hypothermia reduces risk of death and disability in infants with moderate to severe hypoxic ischemic encephalopathy (HIE). Randomized clinical trials of therapeutic hypothermia to date have not included infants with mild HIE because of a perceived good prognosis.

Objective

To test the hypothesis that children with mild HIE have worse neurodevelopmental outcomes than their healthy peers.

Design, setting, and participants

Analysis of pooled data from 4 prospective cohort studies in Cork, Ireland, and Stockholm, Sweden, between January 2007 and August 2015. The dates of data analysis were September 2017 to June 2019. Follow-up was performed at age 18 to 42 months. In this multicenter cohort study, all children were born or treated at the tertiary c

SUBMITTER: Finder M 

PROVIDER: S-EPMC6865301 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature