Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

ABSTRACT:

Importance

Ischemia is an important pathophysiological mechanism after traumatic brain injury (TBI), but its incidence and spatiotemporal patterns are poorly characterized.

Objective

To comprehensively characterize the spatiotemporal changes in cerebral physiology after TBI.

Design, setting, and participants

This single-center cohort study uses 15oxygen positron emission tomography data obtained in a neurosciences critical care unit from February 1998 through July 2014 and analyzed from April 2018 through August 2019. Patients with TBI requiring intracranial pressure monitoring and control participants were recruited.

Exposures

Cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen metabolism (CMRO2), and oxygen extraction fraction.

Main out

SUBMITTER: Launey Y 

PROVIDER: S-EPMC6865302 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature