Neurohormonal Blockade and Clinical Outcomes in Patients With Heart Failure Supported by Left Ventricular Assist Devices.

ABSTRACT:

Importance

Left ventricular assist devices (LVADs) improve outcomes in patients with advanced heart failure, but little is known about the role of neurohormonal blockade (NHB) in treating these patients.

Objective

To analyze the association between NHB blockade and outcomes in patients with LVADs.

Design, setting, and participants

This retrospective cohort analysis of the Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) included patients from more than 170 centers across the United States and Canada with continuous flow LVADs from 2008 to 2016 who were alive with the device in place at 6 months after implant. The data were analyzed between February and November 2019.

Exposures

Patients were stratified based on exposure to NHB and r

SUBMITTER: McCullough M 

PROVIDER: S-EPMC6865330 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature