Brain MRI shows white matter sparing in Kennedy's disease and slow-progressing lower motor neuron disease.

ABSTRACT: The extent of central nervous system involvement in Kennedy's disease (KD) relative to other motor neuron disease (MND) phenotypes still needs to be clarified. In this study, we investigated cortical and white matter (WM) MRI alterations in 25 patients with KD, compared with 24 healthy subjects, 25 patients with sporadic amyotrophic lateral sclerosis (ALS), and 35 cases with lower motor neuron-predominant disease (LMND). LMND patients were clinically differentiated into 24 fast and 11 slow progressors. Whole-brain cortical thickness, WM tract-based spatial statistics and corticospinal tract (CST) tractography analyses were performed. No significant difference in terms of cortical thickness was found between groups. ALS patients showed widespread decreased fractional anisotropy and increase

SUBMITTER: Spinelli EG 

PROVIDER: S-EPMC6865482 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature