Patterns of co-altered brain structure and function underlying neurological soft signs in schizophrenia spectrum disorders.

ABSTRACT: Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co-altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right-handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion techni

SUBMITTER: Hirjak D 

PROVIDER: S-EPMC6865492 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature