Trait Openness and serotonin 2A receptors in healthy volunteers: A positron emission tomography study.

ABSTRACT: Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5-HT_2A R) agonist psilocybin. However, no studies have investigated whether 5-HT_2A R availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy individuals (53 females), the association between 5-HT_2A R binding in neocortex imaged with [¹⁸ F]altanserin or [¹¹ C]Cimbi-36 PET and personality trait Openness was investigated using linear regression models. In these models the influence of sex on the association was also investigated. Trait Openness was assessed with the NEO Personality Inventory-Revised. No significant associations bet

SUBMITTER: Stenbaek DS 

PROVIDER: S-EPMC6865516 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature