A multiparametric analysis of white matter maturation during late childhood and adolescence.

ABSTRACT: White matter development has been well described using diffusion tensor imaging (DTI), but the microstructural processes driving development remain unclear due to methodological limitations. Here, using neurite orientation dispersion and density imaging (NODDI), inhomogeneous magnetization transfer (ihMT), and multicomponent driven equilibrium single-pulse observation of T1/T2 (mcDESPOT), we describe white matter development at the microstructural level in a longitudinal cohort of healthy 6-15 year olds. We evaluated age and gender-related trends in fractional anisotropy (FA), mean diffusivity (MD), neurite density index (NDI), orientation dispersion index (ODI), quantitative ihMT (qihMT), myelin volume fraction (VF_m ), and g-ratio. We found age-related increases of VF_m

SUBMITTER: Geeraert BL 

PROVIDER: S-EPMC6865527 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature