Partially impaired functional connectivity states between right anterior insula and default mode network in autism spectrum disorder.

ABSTRACT: Time-invariant resting-state functional connectivity studies have illuminated the crucial role of the right anterior insula (rAI) in prominent social impairments of autism spectrum disorder (ASD). However, a recent dynamic connectivity study demonstrated that rather than being stationary, functional connectivity patterns of the rAI vary significantly across time. The present study aimed to explore the differences in functional connectivity in dynamic states of the rAI between individuals with ASD and typically developing controls (TD). Resting-state functional magnetic resonance imaging data obtained from a publicly available database were analyzed in 209 individuals with ASD and 298 demographically matched controls. A k-means clustering algorithm was utilized to obtain five dynamic states

SUBMITTER: Guo X 

PROVIDER: S-EPMC6865537 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature