White matter connectivity reductions in the pre-clinical continuum of psychosis: A connectome study.

ABSTRACT: Widespread white matter connectivity disruptions have commonly been reported in schizophrenia. However, it is questionable whether structural connectivity decline is specifically associated with schizophrenia or whether it extends along a continuum of psychosis into the healthy population. Elucidating brain structure changes associated with psychotic-like experiences in healthy individuals is insofar important as it is a necessary first step towards our understanding of brain pathology preceding florid psychosis. High resolution, multishell diffusion-weighted magnetic resonance images (MRI) were acquired from 89 healthy individuals. Whole-brain white matter fibre tracking was performed to quantify the strength of white matter connections. Network-based statistics were applied to white matt

SUBMITTER: Oestreich LKL 

PROVIDER: S-EPMC6865570 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature