Dynamic changes of functional segregation and integration in vulnerability and resilience to schizophrenia.

ABSTRACT: Schizophrenia (SZ) is a highly heritable disease with neurodevelopmental origins and significant functional brain network dysfunction. Functional network is heavily influenced by neurodevelopment processes and can be characterized by the degree of segregation and integration. This study examines functional segregation and integration in SZ and their first-degree relatives (high risk [HR]) to better understand the dynamic changes in vulnerability and resiliency, and disease markers. Resting-state functional magnetic resonance imaging data acquired from 137 SZ, 89 HR, and 210 healthy controls (HCs). Small-worldness σ was computed at voxel level to quantify balance between segregation and integration. Interregional functional associations were examined based on Euclidean distance between regi

SUBMITTER: Duan J 

PROVIDER: S-EPMC6865589 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature