Disrupted brain functional networks in drug-naive children with attention deficit hyperactivity disorder assessed using graph theory analysis.

ABSTRACT: Neuroimaging studies have revealed functional brain network abnormalities in attention deficit hyperactivity disorder (ADHD), but the results have been inconsistent, potentially related to confounding medication effects. Furthermore, specific topological alterations in functional networks and their role in behavioral inhibition dysfunction remain to be established. Resting-state functional magnetic resonance imaging was performed on 51 drug-naïve children with ADHD and 55 age-matched healthy controls. Brain functional networks were constructed by thresholding the partial correlation matrices of 90 brain regions, and graph theory was used to analyze network topological properties. The Stroop test was used to assess cognitive inhibitory abilities. Nonparametric permutation tests were used to

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6865592 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature