Parsing brain structural heterogeneity in males with autism spectrum disorder reveals distinct clinical subtypes.

ABSTRACT: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with considerable neuroanatomical heterogeneity. Thus, how and to what extent the brains of individuals with ASD differ from each other is still unclear. In this study, brain structural MRI data from 356 right-handed, male subjects with ASD and 403 right-handed male healthy controls were selected from the Autism Brain Image Data Exchange database (age range 5-35 years old). Voxel-based morphometry preprocessing steps were conducted to compute the gray matter volume maps for each subject. Individual neuroanatomical difference patterns for each ASD individual were calculated. A data-driven clustering method was next utilized to stratify individuals with ASD into several subtypes. Whole-brain functional connectivity and clinical

SUBMITTER: Chen H 

PROVIDER: S-EPMC6865602 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature