Association Between Antidiabetic Medications and Prostate-Specific Antigen Levels and Biopsy Results.

ABSTRACT:

Importance

Diabetic men appear to have a lower risk of prostate cancer. Whether antidiabetic medications are protective or potentially mask prostate cancer by lowering prostate-specific antigen (PSA) levels is unclear.

Objective

To examine the associations of antidiabetic medication use with (1) PSA levels, (2) frequency of PSA testing, (3) receipt of biopsy following elevated PSA results, and (4) prostate cancer detection at biopsy.

Design, setting, and participants

Population-based cohort study using data from the Stockholm PSA and Biopsy Register. Participants were all prostate cancer-free men aged 40 to 79 years residing in Stockholm County, Sweden, between January 1, 2006, and December 31, 2015. Data were analyzed from November 2018 to March 2019.

Exposures

SUBMITTER: Beckmann K 

PROVIDER: S-EPMC6865613 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature