Abnormalities of hippocampal shape and subfield volumes in medication-free patients with obsessive-compulsive disorder.

ABSTRACT: In this study, we sought to identify alterations of hippocampal shape and subfield volumes in a relatively large sample of medication-free obsessive-compulsive disorder (OCD) patients without comorbid depression. 3D T1-weighted Magnetic Resonance Imaging scans were collected from 81 medication-free OCD patients and 95 age- and sex-matched healthy controls (HC). Total hippocampal volume and volume of eight bilateral subfields were measured using FreeSurfer software. Subregional shape deformity was examined via FSL software. Volumetric and shape differences between groups and correlations with OCD symptoms were examined. The volume of right hippocampus was significantly reduced in OCD patients (p = .001, η² = 0.065). Follow-up analysis of right hemisphere subfields showed reduced

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6865630 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature