Charting shared developmental trajectories of cortical thickness and structural connectivity in childhood and adolescence.

ABSTRACT: The cortex is organised into broadly hierarchical functional systems with distinct neuroanatomical characteristics reflected by macroscopic measures of cortical morphology. Diffusion-weighted magnetic resonance imaging allows the delineation of areal connectivity, changes to which reflect the ongoing maturation of white matter tracts. These developmental processes are intrinsically linked with timing coincident with the development of cognitive function. In this study, we use a data-driven multivariate approach, nonnegative matrix factorisation, to define cortical regions that co-vary together across a large paediatric cohort (n = 456) and are associated with specific subnetworks of cortical connectivity. We find that age between 3 and 21 years is associated with accelerated cortical thinn

SUBMITTER: Ball G 

PROVIDER: S-EPMC6865644 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature