Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.

ABSTRACT: Down's syndrome is a chromosomal disorder that invariably results in both intellectual disability and Alzheimer's disease neuropathology. However, only a limited number of studies to date have investigated intrinsic brain network organisation in people with Down's syndrome, none of which addressed the links between functional connectivity and Alzheimer's disease. In this cross-sectional study, we employed ¹¹ C-Pittsburgh Compound-B (PiB) positron emission tomography in order to group participants with Down's syndrome based on the presence of fibrillar beta-amyloid neuropathology. We also acquired resting state functional magnetic resonance imaging data to interrogate the connectivity of the default mode network; a large-scale system with demonstrated links to Alzheimer's disease

SUBMITTER: Wilson LR 

PROVIDER: S-EPMC6865660 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature