Understanding white matter structural connectivity differences between cognitively impaired and nonimpaired active professional fighters.

ABSTRACT: Long-term traumatic brain injury due to repeated head impacts (RHI) has been shown to be a risk factor for neurodegenerative disorders, characterized by a loss in cognitive performance. Establishing the correlation between changes in the white matter (WM) structural connectivity measures and neuropsychological test scores might help to identify the neural correlates of the scores that are used in daily clinical setting to investigate deficits due to repeated head blows. Hence, in this study, we utilized high angular diffusion MRI (dMRI) of 69 cognitively impaired and 70 nonimpaired active professional fighters from the Professional Fighters Brain Health Study, and constructed structural connectomes to understand: (a) whether there is a difference in the topological WM organization between

SUBMITTER: Mishra VR 

PROVIDER: S-EPMC6865667 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature