Discriminating between neurofibromatosis-1 and typically developing children by means of multimodal MRI and multivariate analyses.

ABSTRACT: Neurofibromatosis Type 1 leads to brain anomalies involving both gray and white matter. The extent and granularity of these anomalies, together with their possible impact on brain activity, is still unknown. In this multicentric cross-sectional study we submitted a sample of 42 typically developing and 38 neurofibromatosis-1 children to a multimodal MRI assessment including T1, diffusion weighted and resting state functional sequences. We used a pipeline involving several features selection steps coupled with multivariate statistical analysis (supporting vector machine) to discriminate between the two groups while having interpretable models. We used MRI indexes measuring macro (gray matter volume) and microstructural (fractional anisotropy, mean diffusivity) characteristics of the brain,

SUBMITTER: Nemmi F 

PROVIDER: S-EPMC6865722 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature