Data-driven approaches for tau-PET imaging biomarkers in Alzheimer's disease.

ABSTRACT: Previous positron emission tomography (PET) studies have quantified filamentous tau pathology using regions-of-interest (ROIs) based on observations of the topographical distribution of neurofibrillary tangles in post-mortem tissue. However, such approaches may not take full advantage of information contained in neuroimaging data. The present study employs an unsupervised data-driven method to identify spatial patterns of tau-PET distribution, and to compare these patterns to previously published "pathology-driven" ROIs. Tau-PET patterns were identified from a discovery sample comprised of 123 normal controls and patients with mild cognitive impairment or Alzheimer's disease (AD) dementia from the Swedish BioFINDER cohort, who underwent [¹⁸ F]AV1451 PET scanning. Associations wi

SUBMITTER: Vogel JW 

PROVIDER: S-EPMC6865737 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature