MEG imaging of recurrent gliomas reveals functional plasticity of hemispheric language specialization.

ABSTRACT: In patients with gliomas, changes in hemispheric specialization for language determined by magnetoencephalography (MEG) were analyzed to elucidate the impact of treatment and tumor recurrence on language networks. Demonstration of reorganization of language networks in these patients has significant implications on the prevention of postoperative functional loss and recovery. Whole-brain activity during an auditory verb generation task was estimated from MEG recordings in a group of 73 patients with recurrent gliomas. Hemisphere of language dominance was estimated using the language laterality index (LI), a measure derived from the task. The initial scan was performed prior to resection; patients subsequently underwent surgery and adjuvant treatment. A second scan was performed upon recurr

SUBMITTER: Traut T 

PROVIDER: S-EPMC6865794 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature