In vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines.

ABSTRACT: Human papillomavirus positive (HPV⁺) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have better outcomes than corresponding HPV^- negative (HPV^-) cancer cases. Our previous study demonstrated that fibroblast growth factor receptor 3 (FGFR3) and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit a (PIK3CA) are often mutated in HPV⁺ cancer. To investigate whether targeted therapy is an option for TSCC/BOTSCC, two HPV⁺ and one HPV^- TSCC/BOTSCC cell lines were tested for their sensitivity towards FGFR and PI3K inhibitors. The HPV⁺ cell lines UM-SCC-47 and UPCI-SCC-154, and the HPV^- cell line UT-SSC-60A were tested by competitive allele-specific TaqMan-PCR for presence/absenc

SUBMITTER: Holzhauser S 

PROVIDER: S-EPMC6865836 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature