Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia.

ABSTRACT: Patients with schizophrenia do not usually achieve remission state even after adequate antipsychotics treatment. Previous studies found significant difference in white matter integrity between patients with good outcomes and those with poor outcomes, but difference is still unclear at individual tract level. This study aimed to use a systematic approach to identify the tracts that were associated with remission state in patients with schizophrenia. We evaluated 91 patients with schizophrenia (remitted, 50; nonremitted, 41) and 50 healthy controls through diffusion spectrum imaging. White matter tract integrity was assessed through an automatic tract-specific analysis method to determine the mean generalized fractional anisotropy (GFA) values of the 76 white matter tract bundles in each par

SUBMITTER: Huang JY 

PROVIDER: S-EPMC6866389 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature