Local functional connectivity suggests functional immaturity in children with attention-deficit/hyperactivity disorder.

ABSTRACT: Previous studies have associated Attention-Deficit/Hyperactivity Disorder (ADHD) with a maturational lag of brain functional networks. Functional connectivity of the human brain changes from primarily local to more distant connectivity patterns during typical development. Under the maturational lag hypothesis, we expect children with ADHD to exhibit increased local connectivity and decreased distant connectivity compared with neurotypically developing (ND) children. We applied a graph-theory method to compute local and distant connectivity levels and cross-sectionally compared them in a sample of 120 children with ADHD and 120 age-matched ND children (age range = 7-17 years). In addition, we measured if potential group differences in local and distant connectivity were stable across the ag

SUBMITTER: Marcos-Vidal L 

PROVIDER: S-EPMC6866394 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature