Structure-function multi-scale connectomics reveals a major role of the fronto-striato-thalamic circuit in brain aging.

ABSTRACT: Physiological aging affects brain structure and function impacting morphology, connectivity, and performance. However, whether some brain connectivity metrics might reflect the age of an individual is still unclear. Here, we collected brain images from healthy participants (N = 155) ranging from 10 to 80 years to build functional (resting state) and structural (tractography) connectivity matrices, both data sets combined to obtain different connectivity features. We then calculated the brain connectome age-an age estimator resulting from a multi-scale methodology applied to the structure-function connectome, and compared it to the chronological age (ChA). Our results were twofold. First, we found that aging widely affects the connectivity of multiple structures, such as anterior cingulate

SUBMITTER: Bonifazi P 

PROVIDER: S-EPMC6866396 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature