The system-neurophysiological basis for how methylphenidate modulates perceptual-attentional conflicts during auditory processing.

ABSTRACT: The ability to selectively perceive and flexibly attend to relevant sensory signals in the environment is essential for action control. Whereas neuromodulation of sensory or attentional processing is often investigated, neuromodulation of interactive effects between perception and attention, that is, high attentional control demand when the relevant sensory information is perceptually less salient than the irrelevant one, is not well understood. To fill this gap, this pharmacological-electroencephalogram (EEG) study applied an intensity-modulated, focused-attention dichotic listening paradigm together with temporal EEG signal decomposition and source localization analyses. We used a double-blind MPH/placebo crossover design to delineate the effects of methylphenidate (MPH)-a dopamine/norep

SUBMITTER: Adelhofer N 

PROVIDER: S-EPMC6866405 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature