Multimodal cortical and hippocampal prediction of episodic-memory plasticity in young and older adults.

ABSTRACT: Episodic memory can be trained in both early and late adulthood, but there is considerable variation in cognitive improvement across individuals. Which brain characteristics make some individuals benefit more than others? We used a multimodal approach to investigate whether volumetric magnetic resonance imaging (MRI) and resting-state functional MRI characteristics of the cortex and hippocampus, brain regions involved in episodic-memory function, were predictive of cognitive improvement after memory training. We hypothesized that these brain characteristics would differentially predict memory improvement in young and older adults, given the vulnerability of cortical regions as well as the hippocampus to healthy aging. Following structural and resting-state activity magnetic resonance scans

SUBMITTER: Brathen ACS 

PROVIDER: S-EPMC6866451 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature