Modulation of network-to-network connectivity via spike-timing-dependent noninvasive brain stimulation.

ABSTRACT: Human cognitive abilities and behavior are linked to functional coupling of many brain regions organized in distinct networks. Gaining insights on the role those networks' dynamics play in cognition and pathology requires their selective, reliable, and reversible manipulation. Here we document the possibility to manipulate the interplay between two brain networks in a controlled manner, by means of a Transcranial Magnetic Stimulation (TMS) protocol inducing spike timing dependent plasticity (STDP). Pairs of TMS pulses at specific inter-stimulus intervals, repeatedly delivered over two negatively correlated nodes of the default mode network (DMN) and the task-positive network (TPN) defined on the basis of individual functional magnetic resonance imaging (fMRI) data, induced a modulation of

SUBMITTER: Santarnecchi E 

PROVIDER: S-EPMC6866459 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature