Network-based decoupling of local gyrification in obsessive-compulsive disorder.

ABSTRACT: Gyrification is associated with cortical maturation and closely linked to neurodevelopmental processes. Obsessive-compulsive disorder has previously been associated with neurodevelopmental risk factors. Using graph theoretical modeling we examined structural covariance patterns to assess potential disruptions in processes associated with neurodevelopment in OCD. In total 97 patients and 92 healthy controls underwent magnetic resonance imaging. Structural covariance networks based on local gyrification indices were constructed using an atlas-based parcellation scheme. Network properties were assessed using the network-based statistic as well as global and local graph theoretical measures. Correlations between gyrification and symptom severity as well as age of disease onset were examined. N

SUBMITTER: Reess TJ 

PROVIDER: S-EPMC6866514 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature