Reduced olfactory bulb volume in depression-A structural moderator analysis.

ABSTRACT:

Background

Removal of the olfactory bulb (OB) leads to depression like behavior in rodents. A link between depression and olfactory function is also established in humans. We hypothesized that the human OB volume relates to depressive state and tested whether such a potential coherence is moderated by structural alterations in other brain regions.

Methods

Eighty-three participants (32 patients with major depression and 51 matched healthy controls) underwent structural MR scanning. Individual OB volumes were compared between patients and controls and the impact of depression and comorbidity was analyzed with multiple regression analysis. Whole-brain voxel-based morphometry revealed structures co-varying with both depressive state and OB volume.

Results

The OB volume of

SUBMITTER: Rottstadt F 

PROVIDER: S-EPMC6866619 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature