Functionally Distinct Connectivity of Developmentally Targeted Striosome Neurons.

ABSTRACT: One long-standing model of striatal function divides the striatum into compartments called striosome and matrix. While some anatomical evidence suggests that these populations represent distinct striatal pathways with differing inputs and outputs, functional investigation has been limited by the methods for identifying and manipulating these populations. Here, we utilize hs599^CreER mice as a new tool for targeting striosome projection neurons and testing their functional connectivity. Extending anatomical work, we demonstrate that striosome neurons receive greater synaptic input from prelimbic cortex, whereas matrix neurons receive greater input from primary motor cortex. We also identify functional differences in how striosome and matrix neurons process excitatory input, provid

SUBMITTER: McGregor MM 

PROVIDER: S-EPMC6866662 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature