The left dorsolateral prefrontal cortex and caudate pathway: New evidence for cue-induced craving of smokers.

ABSTRACT: Although the activation of the prefrontal cortex (PFC) and the striatum had been found in smoking cue induced craving task, whether and how the functional interactions and white matter integrity between these brain regions contribute to craving processing during smoking cue exposure remains unknown. Twenty-five young male smokers and 26 age- and gender-matched nonsmokers participated in the smoking cue-reactivity task. Craving related brain activation was extracted and psychophysiological interactions (PPI) analysis was used to specify the PFC-efferent pathways contributed to smoking cue-induced craving. Diffusion tensor imaging (DTI) and probabilistic tractography was used to explore whether the fiber connectivity strength facilitated functional coupling of the circuit with the smoking cu

SUBMITTER: Yuan K 

PROVIDER: S-EPMC6866730 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature